Should probably put this in the manga section.
It's hard to say but I think Sasuke still has a huge advantage.
After all, Naruto is likely still vulnerable to genjutsu. Even if he isn't, taijutsu is probably a bad idea as well(remember last time), so it's down to ninjutsu... And Sasuke happens to have an element advantage there as well with Katon.
In the end his only hope would probably be sage mode. It's a matter of sage mode versus Mangekyo Sharingan.